Intrinsic connectivity reveals functionally distinct cortico-hippocampal networks in the human brain

Episodic memory depends on interactions between the hippocampus and interconnected neocortical regions. Here, using data-driven analyses of resting-state functional magnetic resonance imaging (fMRI) data, we identified networks that interact with hippocampus—the default mode network (DMN) a “medial temporal network” (MTN) included regions in medial lobe (MTL) precuneus. We observed MTN plays critical role connecting visual to DMN hippocampus. The could be further divided into 3 subnetworks: “posterior medial” (PM) subnetwork comprised posterior cingulate lateral parietal cortices; an “anterior temporal” (AT) temporopolar dorsomedial prefrontal cortex; prefrontal” (MP) primarily cortex (mPFC). These vary their connectivity (FC) along hippocampal long axis represent different kinds information during memory-guided decision-making. Finally, Neurosynth meta-analysis fMRI studies suggests new hypotheses regarding functions subnetworks, providing framework guide future research neural architecture episodic memory.